Studies of stereocontrolled allylation reactions for the total synthesis of phorboxazole A

A highly convergent total synthesis of the potent anticancer agent (+)-phorboxazole A (1) is accomplished. Four components (3–6) are assembled with considerations for control of absolute and relative stereochemistry. Iterative asymmetric allylation methodology addresses key stereochemical features i...

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Hlavní autoři: Williams, David R., Kiryanov, Andre A., Emde, Ulrich, Clark, Michael P., Berliner, Martin A., Reeves, Jonathan T.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Natural Product Synthesis Special Feature
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC514434/
https://ncbi.nlm.nih.gov/pubmed/15277662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402477101
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