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Stereocontrolled total synthesis of (+)-vincristine
An efficient total synthesis of (+)-vincristine has been accomplished through a stereoselective coupling of demethylvindoline and the eleven-membered carbomethoxyverbanamine presursor. Demethylvindoline was prepared by oxidation of 17-hydroxy-11-methoxytabersonine, followed by regioselective acetyla...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514417/ https://ncbi.nlm.nih.gov/pubmed/15141084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401323101 |
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