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The total synthesis of (–)-crispatene

The total synthesis of the molluscan polypropionate (–)-crispatene is described. The synthesis features a palladium-catalyzed cross-coupling to establish a sensitive conjugated tetraene and its Lewis acid-catalyzed cycloisomerization to yield the bicyclo[3.1.0]hexene core of the natural product. The...

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Autors principals: Miller, Aubry K., Byun, Daniel H., Beaudry, Christopher M., Trauner, Dirk
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC514427/
https://ncbi.nlm.nih.gov/pubmed/15273284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401787101
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