Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses

Toll-like receptor (TLR) 7 agonists are effective in topical application for the immunotherapy of skin cancers, but their performance for the systemic treatment of solid tumors is limited by the development of TLR tolerance. In this study, we describe a novel strategy to overcome TLR tolerance and e...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Hotz, Christian, Treinies, Marina, Mottas, Ines, Rötzer, Laurin C., Oberson, Anne, Spagnuolo, Lorenzo, Perdicchio, Maurizio, Spinetti, Thibaud, Herbst, Tina, Bourquin, Carole
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139637/
https://ncbi.nlm.nih.gov/pubmed/27999742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1232219
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