Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses

Toll-like receptor (TLR) 7 agonists are effective in topical application for the immunotherapy of skin cancers, but their performance for the systemic treatment of solid tumors is limited by the development of TLR tolerance. In this study, we describe a novel strategy to overcome TLR tolerance and e...

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發表在:Oncoimmunology
Main Authors: Hotz, Christian, Treinies, Marina, Mottas, Ines, Rötzer, Laurin C., Oberson, Anne, Spagnuolo, Lorenzo, Perdicchio, Maurizio, Spinetti, Thibaud, Herbst, Tina, Bourquin, Carole
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2016
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5139637/
https://ncbi.nlm.nih.gov/pubmed/27999742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1232219
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