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Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells
Adoptive immunotherapy retargeting T cells to CD19 via a chimeric antigen receptor (CAR) is an investigational treatment capable of inducing complete tumor regression of B-cell malignancies when there is sustained survival of infused cells. T-memory stem cells (T(SCM)) retain superior potential for...
שמור ב:
הוצא לאור ב: | Proc Natl Acad Sci U S A |
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Main Authors: | , , , , , , , , , , , , , , |
פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
National Academy of Sciences
2016
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137758/ https://ncbi.nlm.nih.gov/pubmed/27849617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610544113 |
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