Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

Adoptive immunotherapy retargeting T cells to CD19 via a chimeric antigen receptor (CAR) is an investigational treatment capable of inducing complete tumor regression of B-cell malignancies when there is sustained survival of infused cells. T-memory stem cells (T(SCM)) retain superior potential for...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Hurton, Lenka V., Singh, Harjeet, Najjar, Amer M., Switzer, Kirsten C., Mi, Tiejuan, Maiti, Sourindra, Olivares, Simon, Rabinovich, Brian, Huls, Helen, Forget, Marie-Andrée, Datar, Vrushali, Kebriaei, Partow, Lee, Dean A., Champlin, Richard E., Cooper, Laurence J. N.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137758/
https://ncbi.nlm.nih.gov/pubmed/27849617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610544113
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