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Activating and propagating polyclonal gamma delta T cells with broad specificity for malignancies

PURPOSE: To activate and propagate populations of γδT cells expressing polyclonal repertoire of γ and δ TCR chains for adoptive immunotherapy for cancer, which has yet to be achieved. EXPERIMENTAL DESIGN: Clinical-grade artificial antigen presenting cells (aAPC) derived from K562 tumor cells were us...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Deniger, Drew C., Maiti, Sourindra N., Mi, Tiejuan, Switzer, Kirsten C., Ramachandran, Vijaya, Hurton, Lenka V., Ang, Sonny, Olivares, Simon, Rabinovich, Brian A., Huls, Helen, Lee, Dean A., Bast, Robert C., Champlin, Richard E., Cooper, Laurence J.N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233015/
https://ncbi.nlm.nih.gov/pubmed/24833662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3451
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