Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations

T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often accompanied by a loss of normal CD19(+) B cells and humoral immunity. Receptor tyrosine kinase-like orphan receptor-1 (ROR1) is expressed on...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Deniger, Drew C., Yu, Jianqiang, Huls, M. Helen, Figliola, Matthew J., Mi, Tiejuan, Maiti, Sourindra N., Widhopf, George F., Hurton, Lenka V., Thokala, Radhika, Singh, Harjeet, Olivares, Simon, Champlin, Richard E., Wierda, William G., Kipps, Thomas J., Cooper, Laurence J. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451012/
https://ncbi.nlm.nih.gov/pubmed/26030772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128151
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