Bispecific T-cells Expressing Polyclonal Repertoire of Endogenous γδ T-cell Receptors and Introduced CD19-specific Chimeric Antigen Receptor

Even though other γδ T-cell subsets exhibit antitumor activity, adoptive transfer of γδ Tcells is currently limited to one subset (expressing Vγ9Vδ2 T-cell receptor (TCR)) due to dependence on aminobisphosphonates as the only clinically appealing reagent for propagating γδ T cells. Therefore, we dev...

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Detalhes bibliográficos
Main Authors: Deniger, Drew C, Switzer, Kirsten, Mi, Tiejuan, Maiti, Sourindra, Hurton, Lenka, Singh, Harjeet, Huls, Helen, Olivares, Simon, Lee, Dean A, Champlin, Richard E, Cooper, Laurence JN
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3589159/
https://ncbi.nlm.nih.gov/pubmed/23295945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.267
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