Sleeping Beauty Transposition of Chimeric Antigen Receptors Targeting Receptor Tyrosine Kinase-Like Orphan Receptor-1 (ROR1) into Diverse Memory T-Cell Populations

T cells modified with chimeric antigen receptors (CARs) targeting CD19 demonstrated clinical activity against some B-cell malignancies. However, this is often accompanied by a loss of normal CD19(+) B cells and humoral immunity. Receptor tyrosine kinase-like orphan receptor-1 (ROR1) is expressed on...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Deniger, Drew C., Yu, Jianqiang, Huls, M. Helen, Figliola, Matthew J., Mi, Tiejuan, Maiti, Sourindra N., Widhopf, George F., Hurton, Lenka V., Thokala, Radhika, Singh, Harjeet, Olivares, Simon, Champlin, Richard E., Wierda, William G., Kipps, Thomas J., Cooper, Laurence J. N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4451012/
https://ncbi.nlm.nih.gov/pubmed/26030772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128151
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