Manufacture of Clinical-Grade CD19-Specific T Cells Stably Expressing Chimeric Antigen Receptor Using Sleeping Beauty System and Artificial Antigen Presenting Cells

Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to adoptive immunotherapy is based on a second generation CAR (designated CD19RCD28) that signals through a CD28 and CD3-ζ endodomain. T cells...

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書誌詳細
主要な著者: Singh, Harjeet, Figliola, Matthew J., Dawson, Margaret J., Olivares, Simon, Zhang, Ling, Yang, Ge, Maiti, Sourindra, Manuri, Pallavi, Senyukov, Vladimir, Jena, Bipulendu, Kebriaei, Partow, Champlin, Richard E., Huls, Helen, Cooper, Laurence J. N.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669363/
https://ncbi.nlm.nih.gov/pubmed/23741305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064138
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