Chimeric Antigen Receptor (CAR)-Specific Monoclonal Antibody to Detect CD19-Specific T Cells in Clinical Trials

Clinical trials targeting CD19 on B-cell malignancies are underway with encouraging anti-tumor responses. Most infuse T cells genetically modified to express a chimeric antigen receptor (CAR) with specificity derived from the scFv region of a CD19-specific mouse monoclonal antibody (mAb, clone FMC63...

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Detalhes bibliográficos
Main Authors: Jena, Bipulendu, Maiti, Sourindra, Huls, Helen, Singh, Harjeet, Lee, Dean A., Champlin, Richard E., Cooper, Laurence J. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585808/
https://ncbi.nlm.nih.gov/pubmed/23469246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0057838
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