Redirecting T-cell specificity to EGFR using mRNA to self-limit expression of chimeric antigen receptor

Potential for on-target, but off-tissue toxicity limits therapeutic application of genetically modified T cells constitutively expressing chimeric antigen receptors (CARs) from tumor-associated antigens expressed normal tissue, such as epidermal growth factor receptor (EGFR). Curtailing expression o...

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Detalhes bibliográficos
Publicado no:J Immunother
Main Authors: Caruso, Hillary G., Torikai, Hiroki, Zhang, Ling, Maiti, Sourindra, Dai, Jianliang, Do, Kim-Anh, Singh, Harjeet, Huls, Helen, Lee, Dean A., Champlin, Richard E., Heimberger, Amy B., Cooper, Laurence J.N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847343/
https://ncbi.nlm.nih.gov/pubmed/27163741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000126
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