Manufacture of Clinical-Grade CD19-Specific T Cells Stably Expressing Chimeric Antigen Receptor Using Sleeping Beauty System and Artificial Antigen Presenting Cells

Adoptive transfer of T cells expressing a CD19-specific chimeric antigen receptor (CAR) is being evaluated in multiple clinical trials. Our current approach to adoptive immunotherapy is based on a second generation CAR (designated CD19RCD28) that signals through a CD28 and CD3-ζ endodomain. T cells...

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Bibliographische Detailangaben
Hauptverfasser: Singh, Harjeet, Figliola, Matthew J., Dawson, Margaret J., Olivares, Simon, Zhang, Ling, Yang, Ge, Maiti, Sourindra, Manuri, Pallavi, Senyukov, Vladimir, Jena, Bipulendu, Kebriaei, Partow, Champlin, Richard E., Huls, Helen, Cooper, Laurence J. N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669363/
https://ncbi.nlm.nih.gov/pubmed/23741305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064138
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