Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies

Improving the therapeutic efficacy of T cells expressing a chimeric antigen receptor (CAR) represents an important goal in efforts to control B-cell malignancies. Recently an intrinsic strategy has been developed to modify the CAR itself to improve T-cell signaling. Here we report a second extrinsic...

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Détails bibliographiques
Auteurs principaux: Singh, Harjeet, Figliola, Matthew J., Dawson, Margaret J., Huls, Helen, Olivares, Simon, Switzer, Kirsten, Mi, Tiejuan, Maiti, Sourindra, Kebriaei, Partow, Lee, Dean A., Champlin, Richard E., Cooper, Laurence J.N.
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096697/
https://ncbi.nlm.nih.gov/pubmed/21558388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3843
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