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A new approach to simultaneously quantify both TCR α- and β-chain diversity after adoptive immunotherapy

PURPOSE: TCR (T-cell receptor) variable Vα and Vβ gene diversity is a surrogate biomarker for the therapeutic potential of adoptive immunotherapy and cellular immunity. Therefore creating a straightforward, rapid, sensitive, and reliable method to view the global changes of both TCRVα and Vβ transcr...

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Autors principals: Zhang, Minying, Maiti, Sourindra, Bernatchez, Chantale, Huls, Helen, Rabinovich, Brian, Champlin, Richard E., Vence, Luis M., Hwu, Patrick, Radvanyi, Laszlo, Cooper, Laurence J.N.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823368/
https://ncbi.nlm.nih.gov/pubmed/22761473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3234
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