Activation and propagation of tumor infiltrating lymphocytes on clinical-grade designer artificial antigen presenting cells for adoptive immunotherapy of melanoma

PURPOSE: Adoptive cell therapy (ACT) with autologous tumor infiltrating lymphocytes (TIL) is a therapy for metastatic melanoma with response rates up to 50%. However, the generation of the TIL transfer product is challenging, requiring pooled allogeneic normal donor peripheral blood mononuclear cell...

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Hlavní autoři: Forget, Marie-Andrée, Malu, Shruti, Liu, Hui, Toth, Christopher, Maiti, Sourindra, Kale, Charuta, Haymaker, Cara, Bernatchez, Chantale, Huls, Helen, Wang, Ena, Marincola, Francesco M., Hwu, Patrick, Cooper, Laurence J. N., Radvanyi, Laszlo G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4199393/
https://ncbi.nlm.nih.gov/pubmed/25304728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000056
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