Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent anti-tumor activity

Many tumors over express tumor-associated antigens relative to normal tissue, such as epidermal growth factor receptor (EGFR). This limits targeting by human T cells modified to express chimeric antigen receptors (CARs) due to potential for deleterious recognition of normal cells. We sought to gener...

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Bibliografski detalji
Izdano u:Cancer Res
Glavni autori: Caruso, Hillary G., Hurton, Lenka V., Najjar, Amer, Rushworth, David, Ang, Sonny, Olivares, Simon, Mi, Tiejuan, Switzer, Kirsten, Singh, Harjeet, Huls, Helen, Lee, Dean A., Heimberger, Amy B., Champlin, Richard E., Cooper, Laurence J. N.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624228/
https://ncbi.nlm.nih.gov/pubmed/26330164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0139
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