Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent anti-tumor activity

Many tumors over express tumor-associated antigens relative to normal tissue, such as epidermal growth factor receptor (EGFR). This limits targeting by human T cells modified to express chimeric antigen receptors (CARs) due to potential for deleterious recognition of normal cells. We sought to gener...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Res
Egile Nagusiak: Caruso, Hillary G., Hurton, Lenka V., Najjar, Amer, Rushworth, David, Ang, Sonny, Olivares, Simon, Mi, Tiejuan, Switzer, Kirsten, Singh, Harjeet, Huls, Helen, Lee, Dean A., Heimberger, Amy B., Champlin, Richard E., Cooper, Laurence J. N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624228/
https://ncbi.nlm.nih.gov/pubmed/26330164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0139
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