Tuning sensitivity of CAR to EGFR density limits recognition of normal tissue while maintaining potent anti-tumor activity

Many tumors over express tumor-associated antigens relative to normal tissue, such as epidermal growth factor receptor (EGFR). This limits targeting by human T cells modified to express chimeric antigen receptors (CARs) due to potential for deleterious recognition of normal cells. We sought to gener...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Caruso, Hillary G., Hurton, Lenka V., Najjar, Amer, Rushworth, David, Ang, Sonny, Olivares, Simon, Mi, Tiejuan, Switzer, Kirsten, Singh, Harjeet, Huls, Helen, Lee, Dean A., Heimberger, Amy B., Champlin, Richard E., Cooper, Laurence J. N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624228/
https://ncbi.nlm.nih.gov/pubmed/26330164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0139
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