Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the hi...

Full description

Saved in:
Bibliographic Details
Published in:Cell Death Differ
Main Authors: Gebel, Jakob, Luh, Laura M, Coutandin, Daniel, Osterburg, Christian, Löhr, Frank, Schäfer, Birgit, Frombach, Ann-Sophie, Sumyk, Manuela, Buchner, Lena, Krojer, Tobias, Salah, Eidarus, Mathea, Sebastian, Güntert, Peter, Knapp, Stefan, Dötsch, Volker
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136491/
https://ncbi.nlm.nih.gov/pubmed/27716744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.83
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items