Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the hi...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Autores principales: Gebel, Jakob, Luh, Laura M, Coutandin, Daniel, Osterburg, Christian, Löhr, Frank, Schäfer, Birgit, Frombach, Ann-Sophie, Sumyk, Manuela, Buchner, Lena, Krojer, Tobias, Salah, Eidarus, Mathea, Sebastian, Güntert, Peter, Knapp, Stefan, Dötsch, Volker
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136491/
https://ncbi.nlm.nih.gov/pubmed/27716744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.83
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