Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization

Members of the p53 tumor-suppressor family are expressed as multiple isoforms. Isoforms with an N-terminal transactivation domain are transcriptionally active, while those ones lacking this domain often inhibit the transcriptional activity of other family members. In squamous cell carcinomas, the hi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Gebel, Jakob, Luh, Laura M, Coutandin, Daniel, Osterburg, Christian, Löhr, Frank, Schäfer, Birgit, Frombach, Ann-Sophie, Sumyk, Manuela, Buchner, Lena, Krojer, Tobias, Salah, Eidarus, Mathea, Sebastian, Güntert, Peter, Knapp, Stefan, Dötsch, Volker
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136491/
https://ncbi.nlm.nih.gov/pubmed/27716744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.83
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