Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Many neurodegenerative diseases are linked to amyloid aggregation. In Huntington’s disease (HD), neurotoxicity correlates with an increased aggregation propensity of a polyglutamine (polyQ) expansion in exon 1 of mutant huntingtin protein (mHtt). Here we establish how the domains flanking the polyQ...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2016
Предметы:
Biochemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135392/
https://ncbi.nlm.nih.gov/pubmed/27751235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18065
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