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Anti-polyQ antibodies recognize a short polyQ stretch in both normal and mutant huntingtin exon 1
Huntington’s disease (HD) is caused by expansion of a polyglutamine (polyQ) repeat in the huntingtin protein. A structural basis for the apparent transition between normal and disease-causing expanded polyQ repeats of huntingtin is unknown. The ‘linear lattice’ model proposed random-coil structures...
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| 出版年: | J Mol Biol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4520773/ https://ncbi.nlm.nih.gov/pubmed/26047735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.05.023 |
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