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Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
Huntington disease (HD) is a neurodegenerative trinucleotide repeat disorder caused by an expanded poly-glutamine (polyQ) tract in the mutant huntingtin (mHTT) protein. The formation and topology of filamentous mHTT inclusions in the brain (hallmarks of HD implicated in neurotoxicity) remain elusive...
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| Pubblicato in: | Commun Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8266869/ https://ncbi.nlm.nih.gov/pubmed/34239038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02360-2 |
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