TRiC’s tricks inhibit huntingtin aggregation

In Huntington’s disease, a mutated version of the huntingtin protein leads to cell death. Mutant huntingtin is known to aggregate, a process that can be inhibited by the eukaryotic chaperonin TRiC (TCP1-ring complex) in vitro and in vivo. A structural understanding of the genesis of aggregates and t...

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Detalhes bibliográficos
Main Authors: Shahmoradian, Sarah H, Galaz-Montoya, Jesus G, Schmid, Michael F, Cong, Yao, Ma, Boxue, Spiess, Christoph, Frydman, Judith, Ludtke, Steven J, Chiu, Wah
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707056/
https://ncbi.nlm.nih.gov/pubmed/23853712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00710
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