Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT

All chaperonins mediate ATP-dependent polypeptide folding by confining substrates within a central chamber. Intriguingly, the eukaryotic chaperonin TRiC (also called CCT) uses a built-in lid to close the chamber, whereas prokaryotic chaperonins use a detachable lid. Here we determine the mechanism o...

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Bibliografiske detaljer
Main Authors: Booth, Christopher R, Meyer, Anne S, Cong, Yao, Topf, Maya, Sali, Andrej, Ludtke, Steven J, Chiu, Wah, Frydman, Judith
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546500/
https://ncbi.nlm.nih.gov/pubmed/18536725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1436
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