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Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT
All chaperonins mediate ATP-dependent polypeptide folding by confining substrates within a central chamber. Intriguingly, the eukaryotic chaperonin TRiC (also called CCT) uses a built-in lid to close the chamber, whereas prokaryotic chaperonins use a detachable lid. Here we determine the mechanism o...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2546500/ https://ncbi.nlm.nih.gov/pubmed/18536725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1436 |
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