Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Many neurodegenerative diseases are linked to amyloid aggregation. In Huntington’s disease (HD), neurotoxicity correlates with an increased aggregation propensity of a polyglutamine (polyQ) expansion in exon 1 of mutant huntingtin protein (mHtt). Here we establish how the domains flanking the polyQ...

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Enregistré dans:
Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Shen, Koning, Calamini, Barbara, Fauerbach, Jonathan A, Ma, Boxue, Shahmoradian, Sarah H, Serrano Lachapel, Ivana L, Chiu, Wah, Lo, Donald C, Frydman, Judith
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Biochemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135392/
https://ncbi.nlm.nih.gov/pubmed/27751235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18065
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