Tumor hypoxia causes DNA hypermethylation by reducing TET activity

Hypermethylation of tumor suppressor gene (TSG) promoters confers growth advantages to cancer cells, but how these changes arise is poorly understood. Here, we report that tumor hypoxia reduces the activity of oxygen-dependent TET enzymes, which catalyze DNA de-methylation through 5-methylcytosine o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nature
Egile Nagusiak: Thienpont, Bernard, Steinbacher, Jessica, Zhao, Hui, D’Anna, Flora, Kuchnio, Anna, Ploumakis, Athanasios, Ghesquière, Bart, Van Dyck, Laurien, Boeckx, Bram, Schoonjans, Luc, Hermans, Els, Amant, Frederic, Kristensen, Vessela N., Peng Koh, Kian, Mazzone, Massimiliano, Coleman, Mathew, Carell, Thomas, Carmeliet, Peter, Lambrechts, Diether
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133388/
https://ncbi.nlm.nih.gov/pubmed/27533040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19081
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak