Ischemia-Induced DNA Hypermethylation during Kidney Transplant Predicts Chronic Allograft Injury

Background Ischemia during kidney transplant causes chronic allograft injury and adversely affects outcome, but the underlying mechanisms are incompletely understood. In tumors, oxygen shortage reduces the DNA demethylating activity of the ten-11 translocation (TET) enzymes, yielding hypermethylated...

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Dades bibliogràfiques
Publicat a:J Am Soc Nephrol
Autors principals: Heylen, Line, Thienpont, Bernard, Naesens, Maarten, Busschaert, Pieter, Depreeuw, Jeroen, Smeets, Dominiek, Jochmans, Ina, Monbaliu, Diethard, Pirenne, Jacques, Lerut, Evelyne, Ghesquiere, Bart, Kuypers, Dirk, Lambrechts, Diether, Sprangers, Ben
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2018
Matèries:
Clinical Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5967765/
https://ncbi.nlm.nih.gov/pubmed/29610404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017091027
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