Tumor hypoxia causes DNA hypermethylation by reducing TET activity

Hypermethylation of tumor suppressor gene (TSG) promoters confers growth advantages to cancer cells, but how these changes arise is poorly understood. Here, we report that tumor hypoxia reduces the activity of oxygen-dependent TET enzymes, which catalyze DNA de-methylation through 5-methylcytosine o...

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Publicat a:Nature
Autors principals: Thienpont, Bernard, Steinbacher, Jessica, Zhao, Hui, D’Anna, Flora, Kuchnio, Anna, Ploumakis, Athanasios, Ghesquière, Bart, Van Dyck, Laurien, Boeckx, Bram, Schoonjans, Luc, Hermans, Els, Amant, Frederic, Kristensen, Vessela N., Peng Koh, Kian, Mazzone, Massimiliano, Coleman, Mathew, Carell, Thomas, Carmeliet, Peter, Lambrechts, Diether
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133388/
https://ncbi.nlm.nih.gov/pubmed/27533040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19081
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