Tumor hypoxia causes DNA hypermethylation by reducing TET activity

Hypermethylation of tumor suppressor gene (TSG) promoters confers growth advantages to cancer cells, but how these changes arise is poorly understood. Here, we report that tumor hypoxia reduces the activity of oxygen-dependent TET enzymes, which catalyze DNA de-methylation through 5-methylcytosine o...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Thienpont, Bernard, Steinbacher, Jessica, Zhao, Hui, D’Anna, Flora, Kuchnio, Anna, Ploumakis, Athanasios, Ghesquière, Bart, Van Dyck, Laurien, Boeckx, Bram, Schoonjans, Luc, Hermans, Els, Amant, Frederic, Kristensen, Vessela N., Peng Koh, Kian, Mazzone, Massimiliano, Coleman, Mathew, Carell, Thomas, Carmeliet, Peter, Lambrechts, Diether
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5133388/
https://ncbi.nlm.nih.gov/pubmed/27533040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19081
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