DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

BACKGROUND: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcriptional response to hypoxia. RESULTS: We report that HIFs fail...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: D’Anna, Flora, Van Dyck, Laurien, Xiong, Jieyi, Zhao, Hui, Berrens, Rebecca V., Qian, Junbin, Bieniasz-Krzywiec, Pawel, Chandra, Vikas, Schoonjans, Luc, Matthews, Jason, De Smedt, Julie, Minnoye, Liesbeth, Amorim, Ricardo, Khorasanizadeh, Sepideh, Yu, Qian, Zhao, Liyun, De Borre, Marie, Savvides, Savvas N., Simon, M. Celeste, Carmeliet, Peter, Reik, Wolf, Rastinejad, Fraydoon, Mazzone, Massimiliano, Thienpont, Bernard, Lambrechts, Diether
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384226/
https://ncbi.nlm.nih.gov/pubmed/32718321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02087-z
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