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Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation

DNA methylation is a dynamic epigenetic modification with an important role in cell fate specification and reprogramming. The Ten eleven translocation (Tet) family of enzymes converts 5-methylcytosine to 5-hydroxymethylcytosine, which promotes passive DNA demethylation and functions as an intermedia...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Wiehle, Laura, Raddatz, Günter, Musch, Tanja, Dawlaty, Meelad M., Jaenisch, Rudolf, Lyko, Frank, Breiling, Achim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4719427/
https://ncbi.nlm.nih.gov/pubmed/26598602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00587-15
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