Loss of Tet enzymes compromises proper differentiation of embryonic stem cells

Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed during development. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete loss of Tet activity and 5hmC marks in dev...

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Autores principales: Dawlaty, Meelad M., Breiling, Achim, Le, Thuc, Barrasa, M. Inmaculada, Raddatz, Günter, Gao, Qing, Powell, Benjamin E., Cheng, Albert W., Faull, Kym F., Lyko, Frank, Jaenisch, Rudolf
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035811/
https://ncbi.nlm.nih.gov/pubmed/24735881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.03.003
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