Loss of Tet enzymes compromises proper differentiation of embryonic stem cells

Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxy-methylcytosine (5hmC) and are dynamically expressed during development. While loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete loss of Tet activity and 5hmC marks in dev...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Dawlaty, Meelad M., Breiling, Achim, Le, Thuc, Barrasa, M. Inmaculada, Raddatz, Günter, Gao, Qing, Powell, Benjamin E., Cheng, Albert W., Faull, Kym F., Lyko, Frank, Jaenisch, Rudolf
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035811/
https://ncbi.nlm.nih.gov/pubmed/24735881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.03.003
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker