Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC. Tet1 has been implicated in ESC maintenance and lineage specification in vitro but its precise function i...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Dawlaty, Meelad M, Ganz, Kibibi, Powell, Benjamin E, Hu, Yueh-Chiang, Markoulaki, Styliani, Cheng, Albert W, Gao, Qing, Kim, Jongpil, Choi, Sang-Woon, Page, David C, Jaenisch, Rudolf
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154739/
https://ncbi.nlm.nih.gov/pubmed/21816367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.07.010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky