Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

The Tet family of enzymes (Tet1/2/3) converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Mouse embryonic stem cells (mESCs) highly express Tet1 and have an elevated level of 5hmC. Tet1 has been implicated in ESC maintenance and lineage specification in vitro but its precise function i...

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Hoofdauteurs: Dawlaty, Meelad M, Ganz, Kibibi, Powell, Benjamin E, Hu, Yueh-Chiang, Markoulaki, Styliani, Cheng, Albert W, Gao, Qing, Kim, Jongpil, Choi, Sang-Woon, Page, David C, Jaenisch, Rudolf
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154739/
https://ncbi.nlm.nih.gov/pubmed/21816367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.07.010
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