Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in various embryonic and adult tissues. Mice mutant for either Tet1 or Tet2 are viable raising the question whether these enzymes have overlapping roles in development. Here, we have generated Tet1 and Tet2 doubl...

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Hauptverfasser: Dawlaty, Meelad M., Breiling, Achim, Le, Thuc, Raddatz, Günter, Barrasa, M. Inmaculada, Cheng, Albert W., Gao, Qing, Powell, Benjamin E., Li, Zhe, Xu, Mingjiang, Faull, Kym F., Lyko, Frank, Jaenisch, Rudolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3574201/
https://ncbi.nlm.nih.gov/pubmed/23352810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.12.015
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