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Tet1 is critical for neuronal activity-regulated gene expression and memory extinction

The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation of 5-methylcytosine (5mC) to 5-hydroxymethylacytosine (5hmC) and promote DNA demethylation. Despite the abundance of 5hmC and Tet proteins in the brain, little is known about the functions of the neuronal Tet...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Rudenko, Andrii, Dawlaty, Meelad M., Seo, Jinsoo, Cheng, Albert W., Meng, Jia, Le, Thuc, Faull, Kym F., Jaenisch, Rudolf, Tsai, Li-Huei
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543319/
https://ncbi.nlm.nih.gov/pubmed/24050401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.08.003
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