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Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modifi...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3576573/ https://ncbi.nlm.nih.gov/pubmed/22569366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1826 |
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