Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster

Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modifi...

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Библиографические подробности
Главные авторы: Bocker, Michael T., Tuorto, Francesca, Raddatz, Günter, Musch, Tanja, Yang, Feng-Chun, Xu, Mingjiang, Lyko, Frank, Breiling, Achim
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3576573/
https://ncbi.nlm.nih.gov/pubmed/22569366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1826
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