Tet1 Suppresses p21 to Ensure Proper Cell Cycle Progression in Embryonic Stem Cells

Ten eleven translocation 1 (Tet1) is a DNA dioxygenase that promotes DNA demethylation by oxidizing 5-methylcytosine. It can also partner with chromatin-activating and repressive complexes to regulate gene expressions independent of its enzymatic activity. Tet1 is highly expressed in embryonic stem...

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Main Authors: Stephanie Chrysanthou, Julio C. Flores, Meelad M. Dawlaty
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Cells
Assuntos:
Tet1
ESC
cell cycle
p21
proliferation
Acesso em linha:https://www.mdpi.com/2073-4409/11/8/1366
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