High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

Current chemotherapies for T cell acute lymphoblastic leukemia (T-ALL) efficiently reduce tumor mass. Nonetheless, disease relapse attributed to survival of preleukemic stem cells (pre-LSCs) is associated with poor prognosis. Herein, we provide direct evidence that pre-LSCs are much less chemosensit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Gerby, Bastien, Veiga, Diogo F.T., Krosl, Jana, Nourreddine, Sami, Ouellette, Julianne, Haman, André, Lavoie, Geneviève, Fares, Iman, Tremblay, Mathieu, Litalien, Véronique, Ottoni, Elizabeth, Kosic, Milena, Geoffrion, Dominique, Ryan, Joël, Maddox, Paul S., Chagraoui, Jalila, Marinier, Anne, Hébert, Josée, Sauvageau, Guy, Kwok, Benjamin H., Roux, Philippe P., Hoang, Trang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127686/
https://ncbi.nlm.nih.gov/pubmed/27797342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86489
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge