High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

Current chemotherapies for T cell acute lymphoblastic leukemia (T-ALL) efficiently reduce tumor mass. Nonetheless, disease relapse attributed to survival of preleukemic stem cells (pre-LSCs) is associated with poor prognosis. Herein, we provide direct evidence that pre-LSCs are much less chemosensit...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gerby, Bastien, Veiga, Diogo F.T., Krosl, Jana, Nourreddine, Sami, Ouellette, Julianne, Haman, André, Lavoie, Geneviève, Fares, Iman, Tremblay, Mathieu, Litalien, Véronique, Ottoni, Elizabeth, Kosic, Milena, Geoffrion, Dominique, Ryan, Joël, Maddox, Paul S., Chagraoui, Jalila, Marinier, Anne, Hébert, Josée, Sauvageau, Guy, Kwok, Benjamin H., Roux, Philippe P., Hoang, Trang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5127686/
https://ncbi.nlm.nih.gov/pubmed/27797342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86489
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