B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes

B cells have been strongly implicated in the development of human type 1 diabetes and are required for disease in the NOD mouse model. These functions are dependent on B cell antigen receptor (BCR) specificity and expression of MHC, implicating linked autoantigen recognition and presentation to effe...

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Bibliografiske detaljer
Udgivet i:J Clin Med
Main Authors: Packard, Thomas A., Smith, Mia J., Conrad, Francis J., Johnson, Sara A., Getahun, Andrew, Lindsay, Robin S., Hinman, Rochelle M., Friedman, Rachel S., Thomas, James W., Cambier, John C.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126795/
https://ncbi.nlm.nih.gov/pubmed/27834793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm5110098
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