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Silencing of high-affinity insulin-reactive B lymphocytes by anergy and impact of the NOD genetic background in mice
AIMS/HYPOTHESIS: Previous studies have demonstrated that high-affinity insulin-binding B cells (IBCs) silenced by anergy in healthy humans lose their anergy in islet autoantibody-positive individuals with recent-onset type 1 diabetes, and in autoantibody-negative first-degree relatives carrying cert...
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| Publicado no: | Diabetologia |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219930/ https://ncbi.nlm.nih.gov/pubmed/30255377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4730-z |
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