B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigens

Many self-reactive B cells exist in the periphery in a rapidly reversible state of unresponsiveness referred to as anergy. Reversibility of anergy indicates that chronically occupied BCR must transduce non-durable regulatory signals that maintain unresponsiveness. Consistent with such a mechanism, s...

Full description

Saved in:
Bibliographic Details
Published in:J Autoimmun
Main Authors: Akerlund, Janie, Getahun, Andrew, Cambier, John C
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529775/
https://ncbi.nlm.nih.gov/pubmed/26152931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2015.06.007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items