Therapeutic Potential of SH2 Domain-Containing Inositol-5′-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer

Many tumors present with increased activation of the phosphatidylinositol 3-kinase (PI3K)–PtdIns(3,4,5)P(3)–protein kinase B (PKB/Akt) signaling pathway. It has long been thought that the lipid phosphatases SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) and SHIP2 act as tumor suppressors by...

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Main Authors: Fuhler, Gwenny M, Brooks, Robert, Toms, Bonnie, Iyer, Sonia, Gengo, Elizabeth A, Park, Mi-Young, Gumbleton, Matthew, Viernes, Dennis R, Chisholm, John D, Kerr, William G
Format: Artigo
Jezik:Inglês
Izdano: ScholarOne 2011
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269644/
https://ncbi.nlm.nih.gov/pubmed/22033675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00178
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