The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin

SHIP-2 is a phosphoinositidylinositol 3,4,5 trisphosphate (PtdIns[3,4,5]P(3)) 5-phosphatase that contains an NH(2)-terminal SH2 domain, a central 5-phosphatase domain, and a COOH-terminal proline-rich domain. SHIP-2 negatively regulates insulin signaling. In unstimulated cells, SHIP-2 localized in a...

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Main Authors: Dyson, Jennifer M., O'Malley, Cindy J., Becanovic, Jelena, Munday, Adam D., Berndt, Michael C., Coghill, Imogen D., Nandurkar, Harshal H., Ooms, Lisa M., Mitchell, Christina A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150887/
https://ncbi.nlm.nih.gov/pubmed/11739414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200104005
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