The Inositol Polyphosphate 5-Phosphatase, PIPP, Is a Novel Regulator of Phosphoinositide 3-Kinase-dependent Neurite Elongation

The spatial activation of phosphoinositide 3-kinase (PI3-kinase) signaling at the axon growth cone generates phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P(3)), which localizes and facilitates Akt activation and stimulates GSK-3β inactivation, promoting microtubule polymerization and axon...

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Detalhes bibliográficos
Main Authors: Ooms, Lisa M., Fedele, Clare G., Astle, Megan V., Ivetac, Ivan, Cheung, Vanessa, Pearson, Richard B., Layton, Meredith J., Forrai, Ariel, Nandurkar, Harshal H., Mitchell, Christina A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356573/
https://ncbi.nlm.nih.gov/pubmed/16280363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-05-0469
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