The Type Iα Inositol Polyphosphate 4-Phosphatase Generates and Terminates Phosphoinositide 3-Kinase Signals on Endosomes and the Plasma Membrane

Endosomal trafficking is regulated by the recruitment of effector proteins to phosphatidylinositol 3-phosphate [PtdIns(3)P] on early endosomes. At the plasma membrane, phosphatidylinositol-(3,4)-bisphosphate [PtdIns(3,4)P(2)] binds the pleckstrin homology (PH) domain-containing proteins Akt and TAPP...

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Autors principals: Ivetac, Ivan, Munday, Adam D., Kisseleva, Marina V., Zhang, Xiang-Ming, Luff, Susan, Tiganis, Tony, Whisstock, James C., Rowe, Tony, Majerus, Phillip W., Mitchell, Christina A.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2005
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087230/
https://ncbi.nlm.nih.gov/pubmed/15716355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-09-0799
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